P.Chem 2 Summary Anti-Infectives Incomplete

Anti-infective Agents Joseph Lister (19th Century) introduced antiseptics principles for use in surgery and posttraumatic injury. Paul Ehrlich (1881-1900) a microbiologist, a disciple of Robert Koch, began work with a set of bacteriacide dyes and antiparasitic organic arsenicals. His goal was to develop compounds that retained antimicrobial perspiration at the expense of toxicity to the human host. He spile that the dyes and arsenicals could stain tar lower cells selectively and that the antimicrobial properties of the dyes paralleled the detection activity. This stripping was the first demonstration of selective toxicity, the property of chemicals to violent death ace type of organism while not harming another. Ehrlich husking surface the way for the development of the sulfonamides and Penicillins and the elucidation of the mechanisms of their selective toxicity. antecedent to Ehrlichs studies, the local antimicrobial properties of Phenol and Iodine were rise know n, nevertheless the only useful systemic agents were the herbal remedies of cinchona bark for Malaria and Ipecac for amoebic dysentery. Ehrlichs discovery of Compound 606, the effective Antisyphilitic do drugs Salvarsan, was a breakthrough in the treatment of serious, previously untreatable diseases.

1920s where most(prenominal) successful anti-infective agents were based on Group-IIB element Mercury and the Group-VA elements ratsbane and Antimony. Atoxyl (sodium arsanilate and arsphenamine) was utilize for sleeping sickness. Certain dyes such(prenominal) as Gentian purplish and Methylene blue, were also found to be somewhat effective, as were a fe! w chemicals congeners of the quinine molecule. Heavy metal toxicity after(prenominal) treatment with Mercury, Arsenic, and Antimony hard limited usefulness of agents containing these elements. 1950 spacious strides were made in anti-infective therapy. The Sulfonamides and Sulfones, much effective Phenolic compounds such as Hexachlorophene, synthetic antimalarial December 4, 2012 compounds, and several...If you want to get a full essay, edict it on our website: BestEssayCheap.com

If you want to get a full essay, visit our page: cheap essay